arXiv:2605.21645v1 Announce Type: new
Abstract: Adverse Outcome Pathways (AOP) are logic models that causally link biological mechanisms that can be measured in a lab to adverse outcomes, relevant to chemical regulatory endpoints. AOPs contextualize new approach methodologies (NAMs), in vitro and in silico methods used as alternatives to animal testing and the sequential events in an AOP serve as multi-scale models spanning biological scales. The AOP-Wiki serves as the global repository for AOPs. While the AOP-Wiki has played a central role in AOP expansion over the past decade, constraints within the current data model and application infrastructure limit the AOP-Wiki from supporting continued AOP growth and evolution. Yet, the transformative power of agentic AI has re-invigorated AOP-Wiki data modernization efforts at a time when core AOP principles can be harnessed to inform use of AI for aggregating and structuring AOP-relevant information. Seizing upon this momentum, we present AOP-Wiki EMOD 3.0, the third in a series of evidence model prototypes, which concretely demonstrates data model expansions and our vision for how the AOP-Wiki might be transformed to better serve regulatory science and emergent use of AOPs in biomedical and One Health contexts. We aim to lay a foundation to support computationally-generated AOPs and quantitative AOPs (qAOPs) by focussing on solutions for AOP-Wiki internal quality improvement, evidence structuring to enhance AOP FAIRness and AI-readiness, and improved integration between the AOP framework and NAMs to better serve next generation risk assessment.

OpenAI is named a leader in the 2026 Gartner Magic Quadrant for Enterprise AI Coding Agents, with Codex recognized for innovation and enterprise-scale deployment.

arXiv:2605.20189v1 Announce Type: new
Abstract: Despite the remarkable success of large language models (LLMs), they still face bottlenecks while deploying in dynamic, real-world settings with primary challenges being concept drift and the high cost of gradient-based adaptation. Traditional fine-tuning (FT) struggles to adapt to non-stationary data streams without resulting in catastrophic for getting or requiring extensive manual data curation. To address these limitations within the streaming and continual learning paradigm, we propose the Self-Optimizing Lifelong Autonomous Reasoner (SOLAR) which is an open-ended autonomous agent that leverages parameter-level meta-learning to self-improve, treating model weights as an environment for exploration. It initiates the process by consolidating a strong prior over common-sense knowledge making it effective for transfer-learning. By utilizing a multi-level reinforcement learning approach, SOLAR autonomously discovers adaptation strategies, enabling efficient test-time adaptation to unseen domains. Crucially, SOLAR maintains an evolving knowledge base of valid modification strategies, implicitly acting as an episodic memory buffer to balance plasticity (adaptation to new tasks) and stability (retention of meta-knowledge). Experiments demonstrate that SOLAR outperforms strong baselines on common-sense, mathematical, medical, coding, social and logical reasoning tasks, marking a significant step toward autonomous agents capable of lifelong adaptation in evolving environments.

arXiv:2605.20190v1 Announce Type: new
Abstract: Iterative industrial design-simulation optimization is bottlenecked by the CAD-CAE semantic gap: translating simulation feedback into valid geometric edits under diverse, coupled constraints. To fill this gap, we propose COSMO-Agent (Closed-loop Optimization, Simulation, and Modeling Orchestration), a tool-augmented reinforcement learning (RL) framework that teaches LLMs to complete the closed-loop CAD-CAE process. Specifically, we cast CAD generation, CAE solving, result parsing, and geometry revision as an interactive RL environment, where an LLM learns to orchestrate external tools and revise parametric geometries until constraints are satisfied. To make this learning stable and industrially usable, we design a multi-constraint reward that jointly encourages feasibility, toolchain robustness, and structured output validity. In addition, we contribute an industry-aligned dataset that covers 25 component categories with executable CAD-CAE tasks to support realistic training and evaluation. Experiments show that COSMO-Agent training substantially improves small open-source LLMs for constraint-driven design, exceeding large open-source and strong closed-source models in feasibility, efficiency, and stability.

arXiv:2605.20423v1 Announce Type: new
Abstract: Large Language Models (LLMs) perform well on many language tasks, but their Theory of Mind (ToM) reasoning is still uneven in complex social settings. Existing benchmarks, including ExploreToM, do not always test the recursive beliefs and information asymmetries that make these settings difficult. This paper presents OSCToM (Observer-Self Conflict Theory of Mind), an approach for modeling nested belief conflicts in LLM-based ToM tasks. The key case is one in which an observer’s view of another agent conflicts with the observer’s own belief state. Such cases go beyond simple perspective-taking and require recursive, multi-layered reasoning. OSCToM combines reinforcement learning (RL), an extended domain-specific language, and compositional surrogate models to generate observer-self conflicts. In our experiments, OSCToM-8B gives the best overall result among the systems tested. It improves on the reported ExploreToM results on FANToM and remains competitive on Hi-ToM and BigToM. On the information-asymmetric FANToM benchmark, OSCToM reaches 76% accuracy, compared with the 0.2% reported by ExploreToM. The data-synthesis procedure is also 6x more efficient, indicating that targeted training data can help smaller models handle advanced cognitive reasoning. The project code is available at https://github.com/sharminsrishty/osct.